U.S. Highway 64: Waynesboro to Pulaski – Tennessee

Eastbound across southern Middle Tennessee, U.S. Highway 64 offers a scenic and efficient ride between the rural charm of Waynesboro and the historic town of Pulaski. This 46-mile stretch of highway doesn’t just connect two points on a map—it links the edges of the Highland Rim with rolling farmland, wildlife preserves, and a handful of quiet communities that give this part of Tennessee its laid-back character.

Our drive begins in Waynesboro, a small town nestled in the hills of Wayne County. We join U.S. Highway 64 heading east from the junction with Woods Memorial Boulevard. The road quickly opens up into a well-maintained, four-lane divided highway—ideal for making time without sacrificing views. Just a few miles in, we reach a key highlight of the route: the interchange with the Natchez Trace Parkway. If you’re in no hurry, the parkway makes for a beautiful detour, weaving through dense woods and protected lands like the nearby Laurel Hill Wildlife Management Area. Otherwise, staying on US-64 keeps us moving east through open countryside.

Soon after the parkway, we enter Deerfield, a small unincorporated community that marks the halfway point of our journey. This area is classic Tennessee—pastoral fields, scattered homes, and plenty of quiet. East of Deerfield, U.S. 64 curves southeast as it begins a bypass around Lawrenceburg, the largest town along the route. While we avoid downtown traffic thanks to the controlled-access bypass, Lawrenceburg itself is worth a stop if time allows. It’s the seat of Lawrence County and is rich in history, particularly with ties to David Crockett, who once called this region home. The interchange with U.S. Highway 43 provides a quick connection for those heading north toward Columbia or south toward Alabama.

Once clear of Lawrenceburg, the road settles back into its rhythm. Over the next 10 miles, the landscape begins to shift again—rolling hills give way to more structured farmland as we near Giles County. We arrive in Pulaski at the intersection with TN-166, a route that leads south toward Minor Hill and the Alabama state line. But we stay the course on U.S. 64 just a little farther, ending our trip near the heart of town at the intersection with College Street.

Pulaski, the seat of Giles County, offers a mix of classic Southern architecture, a walkable downtown square, and easy access to the University of Tennessee Southern campus. It’s a town where history and small-town living meet, and it makes for a pleasant stop—whether you’re passing through or calling it a day.