U.S. Route 425

Explore U.S. Route 425, a north–south highway running from Natchez, Mississippi to Pine Bluff, Arkansas. Learn about its history, major intersections, and importance to local communities in Mississippi, Louisiana, and Arkansas.

U.S. Route 425 (US 425) is a north–south U.S. Highway that traverses the southern United States, spanning the states of Mississippi, Louisiana, and Arkansas. It runs approximately 220 miles from its southern terminus at Natchez, Mississippi, where it intersects with US 61 and US 84, to its northern end near Pine Bluff, Arkansas, at an intersection with US 65. Although not one of the oldest highways in the U.S. system, US 425 has grown in regional importance as a connector through rural communities and agricultural corridors.

The route winds through the heart of the Mississippi Delta and Deltaic Plain, offering access to smaller towns such as Winnsboro and Bastrop in Louisiana and Hamburg and Monticello in Arkansas. The highway often runs concurrent with other routes, such as LA 15 in Louisiana and US 82 near Crossett, Arkansas. While most of the roadway is two-lane, several segments—particularly near urban areas—have been upgraded to four-lane divided highways for improved traffic flow and safety.

US 425 is not a part of the original 1926 U.S. Highway system; it was commissioned later, with significant portions designated in the 1980s and 1990s. Today, it serves as a vital north–south alternative to more heavily trafficked corridors like US 65 and US 61, and it plays an essential role in local economies tied to agriculture, forestry, and manufacturing.

Discover U.S. Routes

U.S. Highway 425: Pine Bluff to Star City – Arkansas

U.S. Highway 425: Pine Bluff to Star City – Arkansas

Cruise 27 miles south along U.S. Highway 425 from Pine Bluff to Star City through the heart of southeast Arkansas farmland. Discover rural communities, local history, and a scenic stretch of highway connecting key small towns in the region.

US Highway 425: Ferriday to Mississippi – Louisiana

US Highway 425: Ferriday to Mississippi – Louisiana

Drive 12 miles along US Highway 425 from Ferriday, Louisiana, across the Mississippi River into historic Natchez, Mississippi. Explore scenic delta towns, riverfront views, and a key junction with US-84 on this short but memorable route.

U.S. Route 425: Natchez – Mississippi

U.S. Route 425: Natchez – Mississippi

Take a brief but meaningful drive along U.S. Route 425 through Natchez, Mississippi, as we follow this 2-mile segment from Canal Street to its southern end at US-61—linking downtown charm with a gateway to the Delta.

U.S. Route 425: Arkansas to Bastrop – Louisiana

U.S. Route 425: Arkansas to Bastrop – Louisiana

Drive 27 miles south on US-425 from the Arkansas border to Bastrop, Louisiana, through pine forests, farmland, and the scenic Chemin-A-Haut State Park. A peaceful ride through northeastern Louisiana’s bayou country.

U.S. Route 425: US-82 to Louisiana – Arkansas

U.S. Route 425: US-82 to Louisiana – Arkansas

Take a scenic drive along US-425 from US-82 to the Louisiana state line in southern Arkansas. Explore the pine forests, local history, and rural charm of this short but meaningful route through Ashley County.

U.S. Route 425: Monticello to US-82 – Arkansas

U.S. Route 425: Monticello to US-82 – Arkansas

Explore the scenic drive along US Highway 425 from Monticello to US-82 in southeastern Arkansas. This 36-mile route passes through rural towns, farmland, future interstate corridors, and historic communities, offering travelers a peaceful glimpse into Arkansas’ countrys…